Effects of diadenosine polyphosphates on glomerular volume
نویسندگان
چکیده
منابع مشابه
The effects of diadenosine polyphosphates on the cardiovascular system.
Diadenosine polyphosphates are members of a group of dinucleoside polyphosphates that are ubiquitous, naturally occurring molecules. They form a recently identified class of compounds derived from ATP and consist of two adenosine molecules bridged by up to six phosphate groups. These compounds are stored in high concentrations in platelet dense granules and are released when platelets become ac...
متن کاملMesenteric and renal vascular effects of diadenosine polyphosphates (APnA).
Diadenosine polyphosphates (APnA) are endogenous dinucleoside molecules consisting of two adenosine moieties linked via their 5'-ribose positions by a variable number of phosphate groups. APnA have been shown to be present in different cell types and to be released from platelets as well as co-released with catecholamines and ATP from bovine adrenal medulla. Candidate metabolites of APnA are AT...
متن کاملEffects of Diadenosine Polyphosphates on Vasoconstriction and Cytosolic Calcium in Vascular Smooth Muscle and Glomerular Mesangial Cells
The effects of diadenosine tetraphosphate (AP4A), diadenosine pentaphosphate (AP5A), and diadenosine hexaphosphate (AP6A) on the force of renal resistance vessels and aortic strips were measured using a small vessel myograph. Spectrofluorophotometric measurements of cytosolic free calcium concentrations ([Ca2+]i) in cultured rat vascular smooth muscle cells (VSMC) and glomerular mesangial cells...
متن کاملDiinosine polyphosphates, a group of dinucleotides with antagonistic effects on diadenosine polyphosphate receptor.
A new family of dinucleotide derivatives, diinosine polyphosphates, has been synthesized through the use of the enzyme 5' adenylic acid deaminase from Aspergillus sp., starting from the corresponding diadenosine polyphosphates. Functional studies were performed on rat brain synaptic terminals in which a dinucleotide receptor has been described that is specific for adenine dinucleotides. The res...
متن کاملEffects of diadenosine polyphosphates on tear secretion in New Zealand white rabbits.
Extracellular diadenosine polyphosphates play important signaling functions in a number of physiological responses. Here we show that diadenosine polyphosphates are normal constituents of tear fluid and are potent stimulators of tear secretion through their interaction with P2Y receptors. Diadenosine tetraphosphate (Ap(4)A) and Ap(5)A were found in rabbit tears under basal conditions at concent...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2005
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0706149